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Mibrain is made in the size of tablets, with the main ingredients being Tramadol HCl and Acetaminophen. It is used in the treatment of pain relief for moderate lớn severe pain.

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1. Uses of the drug Mibrain

What is Mibrain? Each Mibrain tablet contains 37.5mg of Tramadol HCl and 325mg of Acetaminophen. In particular, Tramadol is an opioid analgesic with non-selective central nervous system effects on some receptors. In addition, this ingredient also inhibits the reabsorption of adrenaline, the release of serotonin. The mechanism of action of Tramadol is similar lớn that of narcotic analgesics but it causes less respiratory depression. Acetaminophen (another name: Paracetamol) is a non-narcotic peripheral analgesic. Compared with non-steroidal anti-inflammatory drugs, Acetaminophen has very few side effects.
Indications for the effective use of Mibrain in pain relief for acute and chronic pain of moderate lớn severe severity. The use of Mibrain is contraindicated in the following cases:
Patients with a history of hypersensitivity lớn Tramadol, Acetaminophen, pain relievers or other ingredients of the drug; Patients with acute alcohol poisoning, poisoning with drugs acting on the central nervous system (sleeping pills, central analgesics, anesthetics, analgesics, psychotropic drugs) because Mibrain can inhibit central nervous system, causing respiratory failure in this group of patients; Patients with liver failure, lung, heart or kidney disease; People who are using MAO drugs; Pregnant and lactating women; Patients with G6PD deficiency; People with acute abdominal pain of unknown cause; Patients with uncontrolled epilepsy; Opioid addicts; Patients with renal failure with creatinine clearance less than thở 30ml/min; Children under 15 years old.

2. Usage and dosage of Mibrain

Mibrain is taken orally. Mibrain should only be used in patients with moderate lớn severe pain, requiring a combination of Tramadol and Acetaminophen. Specific dosages are as follows:
Short-term pain, acute level: Take a dose of 2 tablets/time, the interval between doses is 6 hours, bởi not take more than thở 8 tablets/day; Patients with creatinine clearance less than thở 30ml/min: Dose no more than thở 2 tablets every 12 hours; Elderly patients: The dose should be reduced because the elderly are often more sensitive lớn the adverse effects of the drug; Adjust the dose of Mibrain according lớn the pain level and response of each patient as prescribed by the doctor. Because Mibrain is a combination product, clinical manifestations of overdose will include symptoms of Tramadol toxicity, Acetaminophen toxicity, or both.
Symptoms of Tramadol overdose are respiratory depression, behavioral abnormalities. Serious consequences are central nervous system depression, respiratory failure and even death. To treat an overdose of Tramadol, supportive treatment is required, maintaining adequate oxygen levels for oxygen dialysis.
Symptoms of Acetaminophen overdose within 24 hours are loss of appetite, nausea, vomiting, pallor, depression and sweating. Serious consequences are liver necrosis, leading lớn liver failure and death. If an overdose of Acetaminophen is suspected, it should be treated immediately (even if overdose symptoms have not yet appeared.

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3. Side effects of the drug Mibrain

When using Mibrain (average 6 tablets/day), patients may experience some side effects such as:
Common: Dry mouth, vomiting, diarrhea, constipation, somnolence, loss of appetite, loss of appetite. sleep, dizziness, itchy skin, increased sweating, prostate disorders; Uncommon: Asthenia, headache, fatigue, dizziness, tremor, abdominal pain, dyspepsia, flatulence, constipation, diarrhea, dry mouth, nausea, vomiting, loss of appetite, anxiety disorder anxiety, euphoria, drowsiness, insomnia, nervousness, itchy skin, rash, increased sweating; Rare: Chest pain, syncope, chills, muscle tension, convulsions, migraine (moderate lớn severe), anemia, dyspnoea, urinary disturbances, oliguria, urinary retention, albuminuria, disturbances vision,... When experiencing the side effects of Mibrain, the patient should immediately notify the doctor lớn receive recommendations on the most appropriate treatment.

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4. Be careful when using Mibrain

Some notes patients need lớn remember before and while using Mibrain:
Mibrain should not be used in excess of the indicated dose; Do not use Mibrain with other products containing Tramadol, Acetaminophen, NSAID pain relievers or central pain relievers; Patients should inform their physician about any drug history, especially those with liver or kidney problems, alcoholism, behavioral abnormalities, lung or airway problems, any type of allergy. any allergies (especially lớn codeine); Mibrain can cause dizziness, lightheadedness, and drowsiness. This condition is made worse if alcohol or CNS depressants are used. Therefore, caution should be exercised when using the drug for people who need lớn be alert while driving, operating machinery; Avoid alcohol while taking Mibrain. The reason is because this medicine contains Acetaminophen - a substance that can be harmful lớn the liver. Daily alcohol use, especially when combined with acetaminophen, can increase the risk of liver damage; Use Mibrain with caution in the elderly because this group of people may be more sensitive lớn the side effects of the drug; Withdrawal symptoms may occur if Mibrain is stopped suddenly. Symptoms include: Anxiety, insomnia, sweating, nausea, chills, shivering, diarrhea, upper respiratory tract symptoms, hallucinations, disorientation,... In addition, the patient may have panic attacks, severe depression, paresthesias, etc. If the drug is stopped gradually, the patient can avoid withdrawal symptoms; The use of Mibrain in patients with renal impairment has not been studied, but experience suggests that the dose should be reduced in patients with creatinine clearance less than thở 30 ml/min (2 tablets every 12 hours is recommended); There are no studies on the effects of Mibrain on pregnant women, but the drug can pass through the placenta, causing side effects in the baby. Therefore, the use of this drug is contraindicated in pregnant mothers; In nursing women, if the use of Mibrain must be discontinued, breast-feeding should be discontinued during the dosing period. After stopping the drug, it is advisable lớn wait another 2 days before breastfeeding again.

5. Mibrain drug interactions

Drug interactions of Mibrain involve 2 main ingredients, Tramadol and Acetaminophen. Specifically as follows:
Tramadol drug interactions:
Concurrent use of Tramadol with carbamazepine may reduce the analgesic effect of Tramadol because carbamazepine increases the metabolism of Tramadol, increasing the risk of abnormal changes in behavior Because. Therefore, these 2 drugs should not be used at the same time; Co-administration of Tramadol with Quinidine increases the concentration of Tramadol; Combining Tramadol with CYP2D6 inhibitors such as paroxetine, fluoxetine and amitriptyline may lead lớn inhibition of Tramadol metabolism; When combining Tramadol with MAO inhibitors will increase side effects, including seizures and serotonin syndrome; Concomitant use of Tramadol with digoxin may increase the toxicity of digoxin; Concomitant administration of Tramadol with anticoagulants in the same class as warfarin may prolong prothrombin time. Drug interactions of Acetaminophen:
Long-term use of Acetaminophen in high doses may slightly increase the anticoagulant effect of coumarin and indandion derivatives. Clinically, this effect is not important; Attention should be given lớn the potential for severe hypothermia in patients receiving concomitant Acetaminophen with phenothiazines and antipyretic therapy; Drinking too much alcohol and for a long time can increase the risk of Acetaminophen's hepatotoxicity; Simultaneous use of Acetaminophen with anticonvulsants such as phenytoin, carbamazepine, barbiturates will induce enzymes in the liver microsomes, increase the hepatotoxicity of Acetaminophen (due lớn increased drug metabolism into hepatotoxic substances); Concomitant use of Acetaminophen and isoniazid may increase the risk of hepatotoxicity. The risk of Acetaminophen causing hepatotoxicity is significantly increased in people taking Acetaminophen in larger than thở recommended doses while taking anticonvulsants or isoniazid. Usually, no dose reduction is necessary in patients taking 2 drugs simultaneously, but patients should limit their own use of Acetaminophen while taking anticonvulsants or isoniazid. Patients should take Mibrain exactly as recommended by their doctor lớn ensure the desired pain relief effect and reduce the risk of dangerous side effects.

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